Acetylcholine: Difference between revisions
From Proteopedia
Jump to navigationJump to search
David Canner (talk | contribs) No edit summary |
David Canner (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:acetylcholine.png| thumb | Acetylcholine]] | [[Image:acetylcholine.png| thumb | Acetylcholine]] | ||
<applet load='ACHE2.pdb' size='500' frame='true' align='right' | <applet load='ACHE2.pdb' size='500' frame='true' align='right' | ||
Revision as of 08:41, 1 December 2010
|
Acetylcholinesterase (EC 3.1.1.7, e.g. from Torpedo californica, TcAChE) hydrolysizes the neurotransmitter acetylcholine (ACh), producing choline and an acetate group. ACh directly binds Ser200 (via its nucleophilic Oγ atom) within the catalytic triad (Ser200, His440, and Glu327) of (ACh/TcAChE structure 2ace). The residues Trp84 and Phe330 are also important in the ligand recognition.
Additional Resources
For additional information, see: Alzheimer's Disease
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Alexander Berchansky, Ralf Stephan, Harry Greenblatt, David Canner
