3og7: Difference between revisions
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{{STRUCTURE_3og7| PDB=3og7 | SCENE= }} | {{STRUCTURE_3og7| PDB=3og7 | SCENE= }} | ||
===B-Raf Kinase V600E oncogenic mutant in complex with PLX4032=== | ===B-Raf Kinase V600E oncogenic mutant in complex with PLX4032=== | ||
{{ABSTRACT_PUBMED_20823850}} | {{ABSTRACT_PUBMED_20823850}} | ||
==About this Structure== | ==About this Structure== | ||
[[3og7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG7 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020823850</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| Line 35: | Line 19: | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: V600e]] | [[Category: V600e]] | ||
Revision as of 17:26, 24 March 2013
B-Raf Kinase V600E oncogenic mutant in complex with PLX4032
Template:ABSTRACT PUBMED 20823850
About this Structure
3og7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010 Sep 7. PMID:20823850 doi:10.1038/nature09454
