Cathepsin: Difference between revisions

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New page: left|200px|thumb|Crystal structure wild-type human procathepsin B, [[1pbh]] {{STRUCTURE_1pbh| PDB=1pbh | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, 1pbh...
 
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{{STRUCTURE_1pbh|  PDB=1pbh  | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, [[1pbh]] }}
{{STRUCTURE_1pbh|  PDB=1pbh  | SIZE=300| SCENE= |right|CAPTION=human procathepsin B, [[1pbh]] }}


[[Cathepsin]] (CTS) is a protease which becomes activated at low pH.  It is found in lysosomes.  Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds.  The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS).
[[Cathepsin]] (CTS) is a protease which becomes activated at low pH.  It is found in lysosomes.  Members of the CTS group are denoted as CTSA, CTSB etc and cleave proteins at different peptide bonds.  The CTSs are expressed as an inactive precursor pro-CTS (PCTS) which become active when a long residue prosegment is cleaved off producing the mature CTS (MCTS). The images at the left and at the right correspond to one representative Cathepsin, ''i.e.'' the crystal structure of wild-type human procathepsin B ([[1pbh]]).


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== 3D Structures of Cathepsin ==
=== Procathepsin-B ===
[[1pbh]], [[2pbh]], [[3pbh]] – hPCTSB - human
=== Cathepsin-B mature ===
[[3hhi]] – TbCTSB (mutant) residues 23-340+CA074 – Trypanosoma brucei
[[3k9m]] – hMCTSB+stefin A
[[2ipp]], [[1huc]] – hMCTSB
[[3cbj]], [[3cbk]] – hMCTSB (mutant)+chagasin
[[2dc6]], [[2dc7]], [[2dc8]], [[2dc9]], [[2dca]], [[2dcb]], [[2dcc]], [[2dcd]] – bMCTSB+inhibitor – bovine
[[1sp4]], [[1csb]] – bMCTSB+epoxysuccinyl inhibitor
[[1ito]], [[1qdq]] – bMCTSB +inhibitor
[[1gmy]] - bMCTSB +dipeptidyl nitrile
[[1the]] – rMCTSB (mutant)+butanone inhibitor – rat
[[1cpj]] - rMCTSB (mutant)
[[1cte]] - rMCTSB+pyrimidine inhibitor
=== Cathepsin-C mature ===
[[2djf]], [[2djg]] – hMCTSC +Gly-Phe-CHN2
[[1jqp]] – rMCTSC
[[1k3b]] – hMCTSC
=== Cathepsin-D mature ===
[[1lyw]], [[1lya]] – hMCTSD
[[1lyb]] -  hMCTSD+pepstatin
=== Cathepsin-E mature ===
[[1tzs]] – hMCTSE+activation peptide from CTSE
=== Cathepsin-F mature ===
[[1m6d]] – hMCTSF+piperidine inhibitor
=== Cathepsin-G mature ===
[[1kyn]] – hMCTSG +naphthalene inhibitor
[[1au8]], [[1cgh]] - hMCTSG +phosphonate inhibitor
=== Cathepsin-H mature ===
[[1nb]]3, [[1nb5]] – pMCTSH +stefin A – pig
[[8pch]] -  pMCTSH
=== Cathepsin-K mature ===
[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]] – hMCTSK+ pyrimidine inhibitor
[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor
[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate
[[3c9e]] - hMCTSK + chondroitin-4-sulfate
[[3kwb]] - hMCTSK (mutant)+dioxo-triazine
[[3kw9]] - hMCTSK +triazine
[[1yk8]] - hMCTSK + cyanamide inhibitor
[[1yt7]] - hMCTSK + ketoamide inhibitor
[[2aux]], [[2auz]] - hMCTSK + semicarbazone inhibitor
[[1ayu]], [[1ayv]], [[1ayw]] - hMCTSK + carbohydrazide inhibitor
[[2bdl]], [[1yk7]], [[1tu6]], [[1au3]], [[1au4]] - hMCTSK + pyrrolidine inhibitor
[[1snk]] - hMCTSK + norleucine inhibitor
[[1nl6]], [[1nlj]] - hMCTSK+ azepanone inhibitor
[[1q6k]] - hMCTSK+carbamate inhibitor
[[1au0]] - hMCTSK+ diacylaminoethyl ketone inhibitor
[[1au2]] - hMCTSK+ propanone inhibitor
[[1atk]] – hMCTSK+guanidine inhibitor
[[1vsn]] - hMCTSK+ inhibitor
[[2ato]] – hMCTSK+myocrisin
[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor
[[1u9w]] - hMCTSK+imidazole inhibitor
[[2ftd]] – MCTSK+azepan inhibitor – Macaca mulatta
[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit
=== Cathepsin-L mature ===
[[3f75]] – MCTSL +CTSL propeptide – Toxoplasma gondii
[[2p86]] – TbMCTSL +K11002
[[2nqd]] - CTSL residues 1-220 (mutant)+chagasin – Trypanosoma cruzi
[[1mhw]] – hMCTSL +tripeptide
[[1icf]] – hMCTSL +MHC class II fragment
=== Procathepsin-L1 ===
[[2o6x]] – hPCTSL1 (mutant) – Fasciola hepatica
=== Cathepsin-L1 mature ===
[[3iv2]] – hMCTSL1 (mutant)
[[3k24]] - hMCTSL1 (mutant) +tripeptide
[[3bc3]] - hMCTSL1 +inhibitor
[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor
[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor
=== Cathepsin-L2 mature ===
[[3h6s]] – hMCTSL2+clitocypin
[[1fh0]] – hMCTSL2 (mutant) +vinyl sulfone inhibitor
=== Procathepsin-S ===
[[2c0y]] – hPCTSS (mutant)
=== Cathepsin-S mature ===
[[3n3g]] - hMCTSS+ pyrimidine inhibitor
[[3kwn]] – hMCTSS (mutant)+ thioether acetamide
[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor
[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor
[[2r9m]], [[2r9n]], [[2r9o]] – hMCTSS+piperidine inhibitor
[[2op3]], [[2hhn]], [[2g7y]], [[2hh5]], [[2f1g]] – hMCTSS+aryl inhibitor
[[2fud]], [[2fra]], [[2frq]], [[2ft2]], [[1npz]], [[1nqc]] – hMCTSS+inhibitor
[[2fye]], [[2g6d]] – hMCTSS (mutant)+inhibitor
[[2fq9]], [[1ms6]] – hMCTSS +nitrile inhibitor
[[1glo]] -  hMCTSS (mutant)
=== Procathepsin-X ===
[[1deu]] - hPCTSX
=== Cathepsin-X mature ===
[[1ef7]] – hMCTSX
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