3km8: Difference between revisions
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{{STRUCTURE_3km8| PDB=3km8 | SCENE= }} | {{STRUCTURE_3km8| PDB=3km8 | SCENE= }} | ||
===Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine=== | ===Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/ADA_MOUSE ADA_MOUSE]] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3km8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM8 OCA]. | |||
[[Category: Adenosine deaminase]] | [[Category: Adenosine deaminase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nucleotide metabolism]] | [[Category: Nucleotide metabolism]] | ||