Template:HMGRtemp: Difference between revisions
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[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductasese''' or '''HMGR''') is the rate-controlling enzyme of the metabolic pathway responsible for [http://en.wikipedia.org/wiki/Cholesterol cholesterol] and other isoprenoid biosynthesis, the [http://en.wikipedia.org/wiki/Mevalonate mevalonate pathway]. HMGR is a polytopic, transmembrane protein, containing 8 domains, that is anchored in the membrane of the [http://en.wikipedia.org/wiki/Endoplasmic_Reticulum endoplasmic reticulum].<ref name="Roitelman"/> It is the major target of the Statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. | [[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductasese''' or '''HMGR''') is the rate-controlling enzyme of the metabolic pathway responsible for [http://en.wikipedia.org/wiki/Cholesterol cholesterol] and other isoprenoid biosynthesis, the [http://en.wikipedia.org/wiki/Mevalonate mevalonate pathway]. HMGR is a polytopic, transmembrane protein, containing 8 domains, that is anchored in the membrane of the [http://en.wikipedia.org/wiki/Endoplasmic_Reticulum endoplasmic reticulum].<ref name="Roitelman"/> It is the major target of the Statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. | ||
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==Biological Role== | ==Biological Role== | ||
[[Image: HMG-CoA_reductase_pathway.png|250px|left|thumb| Mevalonate Pathway. Note the early stage at which the Statins interfere in the pathway]] | [[Image: HMG-CoA_reductase_pathway.png|250px|left|thumb| Mevalonate Pathway. Note the early stage at which the Statins interfere in the pathway]] | ||
