User:Eran Hodis/Sandbox7: Difference between revisions
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[[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the Statins interfere in the pathway]] | [[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the Statins interfere in the pathway]] | ||
HMGR is among the most highly regulated enzymes in the human body. It catalyzes the formation of mevalonic acid, the committed step in the biosynthesis of sterols, notably cholesterol and isoprenoids. This reaction can be seen below where HMG-CoA is reduced by NADPH. Despite the poor reputation cholesterol has in the media, it is a critical component of cellular membranes as it is required to establish proper membrane permeability and fluidity. The mevalonate pathway is also responsible for synthesis of the oxygen transporting heme found in red blood cells. <ref name="Meigs">PMID:8626470</ref> | HMGR is among the most highly regulated enzymes in the human body. It catalyzes the formation of mevalonic acid, the committed step in the biosynthesis of sterols, notably cholesterol and isoprenoids. This reaction can be seen below where HMG-CoA is reduced by NADPH. Despite the poor reputation cholesterol has in the media, it is a critical component of cellular membranes as it is required to establish proper membrane permeability and fluidity. The mevalonate pathway is also responsible for synthesis of the oxygen transporting heme found in red blood cells. <ref name="Meigs">PMID:8626470</ref> | ||
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==Structure== | ==Structure== | ||
