3m31: Difference between revisions

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{{Seed}}
[[Image:3m31.jpg|left|200px]]
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{{STRUCTURE_3m31|  PDB=3m31  |  SCENE=  }}  
{{STRUCTURE_3m31|  PDB=3m31  |  SCENE=  }}  
===Structure of the C150A/C295A mutant of S. cerevisiae Ero1p===
===Structure of the C150A/C295A mutant of S. cerevisiae Ero1p===
{{ABSTRACT_PUBMED_20669236}}


 
==Function==
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[[http://www.uniprot.org/uniprot/ERO1_YEAST ERO1_YEAST]] Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Also able to oxidize directly the PDI related protein MPD2. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins. Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.<ref>PMID:9659913</ref> <ref>PMID:9659914</ref> <ref>PMID:10549279</ref> <ref>PMID:11090354</ref> <ref>PMID:12453408</ref>
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{{ABSTRACT_PUBMED_20669236}}


==About this Structure==
==About this Structure==
3M31 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M31 OCA].  
[[3m31]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M31 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20669236</ref><references group="xtra"/>
<ref group="xtra">PMID:020669236</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Fass, D.]]
[[Category: Fass, D.]]
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[[Category: Redox-active center]]
[[Category: Redox-active center]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:09:54 2010''
Retrieved from "https://proteopedia.org/3m31"