3k26: Difference between revisions

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{{Seed}}
[[Image:3k26.png|left|200px]]
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{{STRUCTURE_3k26|  PDB=3k26  |  SCENE=  }}  
{{STRUCTURE_3k26|  PDB=3k26  |  SCENE=  }}  
===Complex structure of EED and trimethylated H3K4===
===Complex structure of EED and trimethylated H3K4===
{{ABSTRACT_PUBMED_20974918}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref><ref>PMID:10581039</ref><ref>PMID:14532106</ref><ref>PMID:15385962</ref><ref>PMID:15231737</ref><ref>PMID:15225548</ref><ref>PMID:16357870</ref><ref>PMID:18285464</ref><ref>PMID:20974918</ref>  
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(as it appears on PubMed at http://www.pubmed.gov), where 20974918 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20974918}}


==About this Structure==
==About this Structure==
3K26 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K26 OCA].  
[[3k26]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K26 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20974918</ref><references group="xtra"/>
<ref group="xtra">PMID:020974918</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]
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[[Category: Wd repeat]]
[[Category: Wd repeat]]
[[Category: Wd40]]
[[Category: Wd40]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:20:40 2010''
Retrieved from "https://proteopedia.org/3k26"