2rjc: Difference between revisions
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==Overview== | ==Overview== | ||
Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 | Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, | L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18026117 18026117] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Allali-Hassani, A.]] | [[Category: Allali-Hassani, A.]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C H.]] | ||
[[Category: Bochkarev, A.]] | [[Category: Bochkarev, A.]] | ||
[[Category: Crombet, L.]] | [[Category: Crombet, L.]] | ||
[[Category: Edwards, A | [[Category: Edwards, A M.]] | ||
[[Category: Herzanych, N.]] | [[Category: Herzanych, N.]] | ||
[[Category: Kozieradzki, I.]] | [[Category: Kozieradzki, I.]] | ||
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[[Category: Loppnau, P.]] | [[Category: Loppnau, P.]] | ||
[[Category: Mackenzie, F.]] | [[Category: Mackenzie, F.]] | ||
[[Category: Min, J | [[Category: Min, J R.]] | ||
[[Category: Ouyang, H.]] | [[Category: Ouyang, H.]] | ||
[[Category: SGC, Structural | [[Category: SGC, Structural Genomics Consortium.]] | ||
[[Category: Sundstrom, M.]] | [[Category: Sundstrom, M.]] | ||
[[Category: Vedadi, M.]] | [[Category: Vedadi, M.]] | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:47:48 2008'' | ||
