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{{Seed}}
[[Image:3map.png|left|200px]]
[[Image:3map.jpg|left|200px]]


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===Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate===
===Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate===


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{{ABSTRACT_PUBMED_20975740}}
{{ABSTRACT_PUBMED_20975740}}


==About this Structure==
==About this Structure==
3MAP is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAP OCA].  
[[3map]] is a 2 chain structure of [[Isocitrate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAP OCA].  
 
==See Also==
*[[Isocitrate dehydrogenase|Isocitrate dehydrogenase]]


==Reference==
==Reference==
<ref group="xtra">PMID:20975740</ref><references group="xtra"/>
<ref group="xtra">PMID:020975740</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ding, J.]]
[[Category: Ding, J.]]
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:48:45 2010''

Revision as of 08:40, 27 July 2012

File:3map.png

Template:STRUCTURE 3map

Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate

Template:ABSTRACT PUBMED 20975740

About this Structure

3map is a 2 chain structure of Isocitrate dehydrogenase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Yang B, Zhong C, Peng Y, Lai Z, Ding J. Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res. 2010 Nov;20(11):1188-200. Epub 2010 Oct 26. PMID:20975740 doi:10.1038/cr.2010.145

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