3lgu: Difference between revisions
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{{STRUCTURE_3lgu| PDB=3lgu | SCENE= }} | {{STRUCTURE_3lgu| PDB=3lgu | SCENE= }} | ||
===Y162A mutant of the DegS-deltaPDZ protease=== | ===Y162A mutant of the DegS-deltaPDZ protease=== | ||
{{ABSTRACT_PUBMED_20739286}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DEGS_ECOLI DEGS_ECOLI]] When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMPs) and then initiates RseA (anti sigma-E factor) degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by RseP. This cascade that ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly.<ref>PMID:12183369</ref> <ref>PMID:19695325</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3lgu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGU OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020739286</ref><references group="xtra"/><references/> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Grant, R A..]] | [[Category: Grant, R A..]] | ||
| Line 34: | Line 21: | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Stress-sensor]] | [[Category: Stress-sensor]] | ||