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| <applet load="" size="480" color="" frame="true" spin="on" Scene ="User:David_Canner/Sandbox_crestor/Rosu/1" align="right" caption="Rosuvastatin, also known as Crestor"/>
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| ===Better Known as: Actos=== | | ===Better Known as: Actos=== |
| * Marketed By: Takeda Pharmaceuticals<br /> | | * Marketed By: Takeda Pharmaceuticals<br /> |
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| * Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States. | | * Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States. |
| * The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information | | * The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information |
| ===Mechanism of Action===
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|
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| ===Pharmacokinetics===
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| {| class="wikitable" border="1" width="40%" style="text-align:center"
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| |-
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| ! colspan="6" align="center"| Glitazone Comparison
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| |-
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| ! Parameter
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| ! [[Pioglitazone]] (Actos)
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| ! [[Rosiglitazone]] (Avandia)
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|
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| |-
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| ! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)
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| !
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| !
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|
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| |-
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| ! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml)
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| !
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| !
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| |-
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| ! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
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| !
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| !
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| |-
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| ! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%)
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| ! 99
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| ! 99
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| |-
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| ! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
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| ! 3-7
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| ! 3-4
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| |-
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| ! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
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| !
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| !
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| |-
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| ! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
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| !
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| !
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| |-
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| ! Equivalent Dosage (mg)
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| !
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| !
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| |-
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| ! Metabolism
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| ! Hepatic <br/>(CYP2C8)
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| ! Hepatic <br/>(CYP2C8)
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| |}
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| ===Effectiveness and Side Effects===
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| ====Effectiveness====
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| ====Side Effects====
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| ===Interesting Facts===
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| ===The Jist===
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| ===References=== | | ===References=== |
