Pioglitazone: Difference between revisions

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 * Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.
 * The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information
+===Pharmacokinetics===
+{| class="wikitable" border="1" width="40%" style="text-align:center"
+|-
+!  colspan="6" align="center"| Glitazone [[Pharmaceutical_Drugs#Pharmacokinetics_Translated|Pharmacokinetics]] Comparison at Equivalent Dosages <ref>doi: 10.1111/j.1365-2125.2007.02986.x</ref><ref>PMID:18997160</ref><ref>PMID: 9454824</ref><ref>PMID: 17594391</ref>
+|-
+! Parameter
+! [[Pioglitazone]] (Actos)
+! [[Rosiglitazone]] (Avandia)
+|-
+! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)
+! 1.8
+! 1
+|-
+! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml)
+! 617
+! 361
+|-
+! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%)
+! 83
+! 99
+|-
+! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%)
+! 99
+! 99
+|-
+! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
+! 3-8
+! 3-4
+|-
+! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
+! 6244
+! 2024
+|-
+! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
+! 360
+! 10
+|-
+! Equivalent Dosage (mg)
+! 30
+! 4
+|-
+! Metabolism
+! Hepatic <br/>(CYP2C8)
+! Hepatic <br/>(CYP2C8)
+|}
 ===References===

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