AZT-resistant HIV-1 reverse transcriptase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 37: | Line 37: | ||
==AZT Resistance== | ==AZT Resistance== | ||
There are two basic types of resistance mechanisms currently known for HIV-1: | There are two basic types of resistance mechanisms currently known for HIV-1: | ||
1. exclusion- discrimination between AZTTP and dTTP at the time that AZTTP is incorporated | 1. exclusion- discrimination between AZTTP and dTTP at the time that AZTTP is incorporated | ||
2. excision- removal of AZTTP from the viral DNA after it has been incorporated into the host genome | 2. excision- removal of AZTTP from the viral DNA after it has been incorporated into the host genome | ||
