3nxd: Difference between revisions

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{{Seed}}
[[Image:3nxd.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3nxd", creates the "Structure Box" on the page.
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{{STRUCTURE_3nxd|  PDB=3nxd  |  SCENE=  }}  
{{STRUCTURE_3nxd|  PDB=3nxd  |  SCENE=  }}  
===JC polyomavirus VP1 in complex with LSTc===
===JC polyomavirus VP1 in complex with LSTc===
{{ABSTRACT_PUBMED_20951965}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/VP1_POVJC VP1_POVJC]] Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with a N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids on the cell surface to provide virion attachment to target cell. The serotonergic receptor 5HT2AR also acts as a cellular receptor for JCV on human glial cells. Once attached, the virions enter predominantly by a ligand-inducible clathrin-dependent pathway and traffic to the ER. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA at nuclear domains called promyelocytic leukemia (PML) bodies, and participates in rearranging nucleosomes around the viral DNA.<ref>PMID:10666259</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20951965}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20951965 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20951965}}


==About this Structure==
==About this Structure==
3NXD is a 5 chains structure with sequences from [http://en.wikipedia.org/wiki/Jc_polyomavirus Jc polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NXD OCA].  
[[3nxd]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Jc_polyomavirus Jc polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NXD OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20951965</ref><references group="xtra"/>
<ref group="xtra">PMID:020951965</ref><references group="xtra"/><references/>
[[Category: Jc polyomavirus]]
[[Category: Jc polyomavirus]]
[[Category: Neu, U.]]
[[Category: Neu, U.]]
Line 31: Line 18:
[[Category: Major capsid protein]]
[[Category: Major capsid protein]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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Retrieved from "https://proteopedia.org/3nxd"