3bch: Difference between revisions
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New page: left|200px<br /><applet load="3bch" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bch, resolution 2.15Å" /> '''Crystal Structure of... |
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caption="3bch, resolution 2.15Å" /> | caption="3bch, resolution 2.15Å" /> | ||
'''Crystal Structure of the Human Laminin Receptor Precursor'''<br /> | '''Crystal Structure of the Human Laminin Receptor Precursor'''<br /> | ||
==Overview== | |||
The human laminin receptor (LamR) interacts with many ligands, including laminin, prions, Sindbis virus, and the polyphenol (-)-epigallocatechin-3-gallate (EGCG), and has been implicated in a number of diseases. LamR is overexpressed on tumor cells, and targeting LamR elicits anti-cancer effects. Here, we report the crystal structure of human LamR, which provides insights into its function and should facilitate the design of novel therapeutics targeting LamR. | |||
==About this Structure== | ==About this Structure== | ||
3BCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCH OCA]. | 3BCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCH OCA]. | ||
==Reference== | |||
Crystal structure of the human laminin receptor precursor., Jamieson KV, Wu J, Hubbard SR, Meruelo D, J Biol Chem. 2008 Feb 8;283(6):3002-5. Epub 2007 Dec 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18063583 18063583] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hubbard, S | [[Category: Hubbard, S R.]] | ||
[[Category: Jamieson, K | [[Category: Jamieson, K V.]] | ||
[[Category: Meruelo, D.]] | [[Category: Meruelo, D.]] | ||
[[Category: Wu, J.]] | [[Category: Wu, J.]] | ||
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[[Category: ribosomal protein]] | [[Category: ribosomal protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:49 2008'' | ||
