Leucine-rich repeat: Difference between revisions

Revision as of 02:48, 19 November 2010

A large family of over 60,000 horseshoe- or arc-shaped proteins named for a repeated motif that always contains leucine.^[1]

Lamprey Variable Lymphocyte Receptor (3e6j), resolution 1.67Å (initial scene)

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

Articles in Proteopedia concerning Leucine-rich repeat proteins include:

Ligands:

BMA, NAG, SO4

Gene:

CGA (Homo sapiens), FSHB (Homo sapiens), FSHR (Homo sapiens)

Structural annotation:
Resources:	CATH : 1Xwda00, 1Xwdb00, 1Xwdd00, 1Xwde00 InterPro : Ipr000476, Ipr002400, Ipr006208, Ipr001545, Ipr000276, Ipr001611, Ipr002131, Ipr002272, Ipr000372 Pfam : PF00236, PF00007, PF01462, PF00560 UniProt : P01215, P01225, P23945

Functional annotation:
Cellular component:	extracellular region soluble fraction membrane plasma membrane integral to membrane
Biological process:	signal transduction cell-cell signaling spermatogenesis Sertoli cell proliferation female gamete generation ovarian follicle development female pregnancy gonad development G-protein coupled receptor protein signaling pathway female gonad development
Molecular function:	hormone activity follicle-stimulating hormone activity protein heterodimerization activity signal transducer activity protein binding follicle-stimulating hormone receptor activity G-protein coupled receptor activity protein-hormone receptor activity receptor activity rhodopsin-like receptor activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

To view automatically seeded indices concerning Leucine-rich repeat proteins, see:

↑ Matsushima N, Miyashita H, Mikami T, Kuroki Y. A nested leucine rich repeat (LRR) domain: the precursor of LRRs is a ten or eleven residue motif. BMC Microbiol. 2010 Sep 9;10:235. PMID:20825685 doi:10.1186/1471-2180-10-235

doi: https://dx.doi.org/11751054/ref><refgroup="xtra">PMID:17192264
Matsushima N, Tanaka T, Enkhbayar P, Mikami T, Taga M, Yamada K, Kuroki Y. Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors. BMC Genomics. 2007 May 21;8:124. PMID:17517123 doi:10.1186/1471-2164-8-124
Matsushima N, Tachi N, Kuroki Y, Enkhbayar P, Osaki M, Kamiya M, Kretsinger RH. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. Cell Mol Life Sci. 2005 Dec;62(23):2771-91. PMID:16231091 doi:10.1007/s00018-005-5187-z
Kajava AV, Kobe B. Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Sci. 2002 May;11(5):1082-90. PMID:11967365 doi:10.1110/ps.4010102

Revision as of 02:47, 19 November 2010 view source Wayne Decatur (talk \| contribs) Editor, widgeteditor 7,824 edits m New page: A large family of over 60,000 horseshoe- or arc-shaped proteins named for a repeated motif that always contains leucine.<ref>PMID: 20825685</ref> {{Structure \|PDB= 3e6j \|SIZE=400\|SCENE=Lam...		Revision as of 02:48, 19 November 2010 view source Wayne Decatur (talk \| contribs) Editor, widgeteditor 7,824 edits mNo edit summary Newer edit →
Line 34:		Line 34:

	==Additional Literature==		==Additional Literature==
	<ref group="xtra">PMID: 11751054/ref><ref group="xtra">PMID: 17192264</ref><ref group="xtra">PMID: 17517123</ref><ref group="xtra">PMID: 16231091</ref><ref group="xtra">PMID: 11967365</ref><references group="xtra"/		<ref group="xtra">PMID: 11751054/ref><ref group="xtra">PMID: 17192264</ref><ref group="xtra">PMID: 17517123</ref><ref group="xtra">PMID: 16231091</ref><ref group="xtra">PMID: 11967365</ref><references group="xtra"/>