3b8z: Difference between revisions

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==Overview==

Aggrecanase-2 [a disintegrin and metalloproteinase with thrombospondin, motifs-5 (ADAMTS-5)], a member of the ADAMTS protein family, is critically, involved in arthritic diseases because of its direct role in cleaving the, cartilage component aggrecan. The catalytic domain of aggrecanase-2 has, been refolded, purified, crystallized and its 3-dimensional structure, determined to 1.4A resolution in the presence of an inhibitor. A high, resolution structure of an ADAMTS/aggrecanase protein provides an, opportunity for the development of therapeutics to treat osteoarthritis.

Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.

==About this Structure==

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==Reference==

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2007 Nov 8;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17991750 17991750]

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17991750 17991750]

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Mathis, K.J.]]

[[Category: Mathis, K J.]]

[[Category: Shieh, H.S.]]

[[Category: Shieh, H S.]]

[[Category: Tomasselli, A.]]

[[Category: Tortorella, M.D.]]

[[Category: Tortorella, M D.]]

[[Category: Williams, J.M.]]

[[Category: Williams, J M.]]

[[Category: 294]]

[[Category: CA]]

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[[Category: hydrolase]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Aggrecanase-2 [a disintegrin and metalloproteinase with thrombospondin, motifs-5 (ADAMTS-5)], a member of the ADAMTS protein family, is critically, involved in arthritic diseases because of its direct role in cleaving the, cartilage component aggrecan. The catalytic domain of aggrecanase-2 has, been refolded, purified, crystallized and its 3-dimensional structure, determined to 1.4A resolution in the presence of an inhibitor. A high, resolution structure of an ADAMTS/aggrecanase protein provides an, opportunity for the development of therapeutics to treat osteoarthritis.
+Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
 ==About this Structure==
@@ Line 10: / Line 10: @@
 ==Reference==
-High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2007 Nov 8;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17991750 17991750]
+High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17991750 17991750]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Mathis, K.J.]]
+[[Category: Mathis, K J.]]
-[[Category: Shieh, H.S.]]
+[[Category: Shieh, H S.]]
 [[Category: Tomasselli, A.]]
-[[Category: Tortorella, M.D.]]
+[[Category: Tortorella, M D.]]
-[[Category: Williams, J.M.]]
+[[Category: Williams, J M.]]
 [[Category: 294]]
 [[Category: CA]]
@@ Line 24: / Line 24: @@
 [[Category: hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:47:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:18 2008''