3m3c: Difference between revisions

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{{Seed}}
[[Image:3m3c.jpg|left|200px]]
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{{STRUCTURE_3m3c|  PDB=3m3c  |  SCENE=  }}  
{{STRUCTURE_3m3c|  PDB=3m3c  |  SCENE=  }}  
===Crystal Structure of Agrocybe aegerita lectin AAL complexed with p-Nitrophenyl TF disaccharide===
===Crystal Structure of Agrocybe aegerita lectin AAL complexed with p-Nitrophenyl TF disaccharide===
{{ABSTRACT_PUBMED_20530247}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>
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{{ABSTRACT_PUBMED_20530247}}


==About this Structure==
==About this Structure==
3M3C is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3C OCA].  
[[3m3c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3C OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20530247</ref><references group="xtra"/>
<ref group="xtra">PMID:020530247</ref><references group="xtra"/><references/>
[[Category: Agrocybe aegerita]]
[[Category: Agrocybe aegerita]]
[[Category: Feng, L.]]
[[Category: Feng, L.]]
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[[Category: Nuclease]]
[[Category: Nuclease]]
[[Category: Thomsen-friedenreich disaccharide]]
[[Category: Thomsen-friedenreich disaccharide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  1 11:30:35 2010''

Revision as of 23:03, 10 April 2013

Template:STRUCTURE 3m3c

Crystal Structure of Agrocybe aegerita lectin AAL complexed with p-Nitrophenyl TF disaccharide

Template:ABSTRACT PUBMED 20530247

Function

[ATLE_AGRAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.[1]

About this Structure

3m3c is a 2 chain structure with sequence from Agrocybe aegerita. Full crystallographic information is available from OCA.

Reference

  1. Feng L, Sun H, Zhang Y, Li DF, Wang DC. Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen. FASEB J. 2010 Oct;24(10):3861-8. Epub 2010 Jun 7. PMID:20530247 doi:10.1096/fj.10-159111
  1. ↑ Zhao C, Sun H, Tong X, Qi Y. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem J. 2003 Sep 1;374(Pt 2):321-7. PMID:12757412 doi:10.1042/BJ20030300

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