Galantamine: Difference between revisions

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===Mechanism of Action===

Galantamine is a potent [[Acetylcholinesterase]] (AChE) inhibitor to the active site of <scene name='Galantamine/Ache/1'>AChE</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Galantamine binds to the same active site gorge as acetylcholine <scene name='Galantamine/Binding/1'>interacting with the residues</scene> Glu 199, Phe 330, Trp 84, His 440, Phe 288, PHe 290, Tyr 121, Phe 331, Gly 119, Ser 200, Gly 118, and Gly 117 to tightly bind to AChE<ref name="Guillou">PMID:15563167</ref>. These interactions, which are primarily hydrophobic and pi stacking interactions, allow Galantamine outcompete Acetylcholine for the AChE active site.

Galantamine is a potent [[Acetylcholinesterase]] (AChE) inhibitor to the active site of <scene name='Galantamine/Ache/1'>AChE</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Galantamine binds to the same active site gorge as acetylcholine <scene name='Galantamine/Binding/1'>interacting with the residues</scene> Glu 199, Phe 330, Trp 84, His 440, Phe 288, PHe 290, Tyr 121, Phe 331, Gly 119, Ser 200, Gly 118, and Gly 117 to tightly bind to AChE.<ref name="Guillou">PMID:15563167</ref> These interactions, which are primarily hydrophobic and pi stacking interactions, allow Galantamine outcompete Acetylcholine for the AChE active site.

===Pharmacokinetics===

Galantamine: Difference between revisions

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@@ Line 10: / Line 10: @@
 ===Mechanism of Action===
-Galantamine is a potent [[Acetylcholinesterase]] (AChE) inhibitor to the active site of <scene name='Galantamine/Ache/1'>AChE</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Galantamine binds to the same active site gorge as acetylcholine <scene name='Galantamine/Binding/1'>interacting with the residues</scene> Glu 199, Phe 330, Trp 84, His 440, Phe 288, PHe 290, Tyr 121, Phe 331, Gly 119, Ser 200, Gly 118, and Gly 117 to tightly bind to AChE<ref name="Guillou">PMID:15563167</ref>. These interactions, which are primarily hydrophobic and pi stacking interactions, allow Galantamine outcompete Acetylcholine for the AChE active site.
+Galantamine is a potent [[Acetylcholinesterase]] (AChE) inhibitor to the active site of <scene name='Galantamine/Ache/1'>AChE</scene>. By inhibiting AChE, the important neurotransmitter, [[acetylcholine]], is degraded at a slower rate, helping reverse the marked decrease in neuronal function evident in [[Alzheimer's Disease]] patients. Galantamine binds to the same active site gorge as acetylcholine <scene name='Galantamine/Binding/1'>interacting with the residues</scene> Glu 199, Phe 330, Trp 84, His 440, Phe 288, PHe 290, Tyr 121, Phe 331, Gly 119, Ser 200, Gly 118, and Gly 117 to tightly bind to AChE.<ref name="Guillou">PMID:15563167</ref> These interactions, which are primarily hydrophobic and pi stacking interactions, allow Galantamine outcompete Acetylcholine for the AChE active site.
 ===Pharmacokinetics===