|
|
| Line 135: |
Line 135: |
| ! Hepatic (CYP3A4) | | ! Hepatic (CYP3A4) |
| |} | | |} |
| ===Pharmacokinetics===
| |
| {| class="wikitable" border="1" width="95%" style="text-align:center"
| |
| |-
| |
| ! colspan="37" align="center"| HIV Protease Inhibitor Resistance Profile <ref>PMID:17646201</ref><ref>PMID: 20068260</ref><ref>PMID: 14724329</ref>
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |-
| |
| ! Inhibitor/Mutation Site
| |
| !L10
| |
| !I13
| |
| !G16
| |
| !K20
| |
| !L24
| |
| !D30
| |
| !V32
| |
| !L33
| |
| !E34
| |
| !E35
| |
| !M36
| |
| !K43
| |
| !M46
| |
| !I47
| |
| !G48
| |
| !I50
| |
| !F53
| |
| !I54
| |
| !D60
| |
| !I62
| |
| !L63
| |
| !I64
| |
| !H69
| |
| !A71
| |
| !G73
| |
| !T74
| |
| !L76
| |
| !V77
| |
| !V82
| |
| !N83
| |
| !I84
| |
| !I85
| |
| !N88
| |
| !L89
| |
| !L90
| |
| !I93
| |
| |}
| |
|
| |
|
| |
| ===References=== | | ===References=== |
| <references/> | | <references/> |
| __NOEDITSECTION__ | | __NOEDITSECTION__ |
| __NOTOC__ | | __NOTOC__ |