Colicin A: Difference between revisions
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==Mechanism of uptake== | ==Mechanism of uptake== | ||
Colicin A binds to the BtuB Vitamin B12 outer membrane receptor of the target cell, and uses the [[Tol]] system to translocate across the membrane, specifically TolQRAB, alongside the OmpF protein. Its use of the Tol system means that Colicin A is in the A group of colicins. | Colicin A binds to the BtuB Vitamin B12 outer membrane receptor of the target cell, and uses the [[Tol]] system to translocate across the membrane, specifically TolQRAB, alongside the OmpF protein. Its use of the Tol system means that Colicin A is in the A group of colicins. | ||
==Killing Activities== | ==Killing Activities== | ||
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Col A when present in an <i>E. coli</i> cell is able to affect macromolecular synthesis throughout the cell, affecting many of the processes in the cell. One such affected system is nucleic acid synthesis; it is halted very soon after Col A is added to the system<ref>PMID:4905544 </ref>. | Col A when present in an <i>E. coli</i> cell is able to affect macromolecular synthesis throughout the cell, affecting many of the processes in the cell. One such affected system is nucleic acid synthesis; it is halted very soon after Col A is added to the system<ref>PMID:4905544 </ref>. | ||
Through its affect on macromolecular synthesis it also affects certain permease activities, such as the uptake of labelled isoleucine<ref> PMID:4905544 </ref>. | Through its affect on macromolecular synthesis it also affects certain permease activities, such as the uptake of labelled isoleucine<ref> PMID:4905544 </ref>. | ||
==References== | |||
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