3ndm: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[3ndm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDM OCA]. | |||
==Reference== | ==Reference== | ||
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[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 20:46, 14 March 2011
Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
Template:ABSTRACT PUBMED 20471253
About this Structure
3ndm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. Epub 2010 Apr 21. PMID:20471253 doi:10.1016/j.bmcl.2010.04.069
- Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A 3rd, Schlyer S, Smith JD, Turner MR, Wu F, Young ER. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5153-6. Epub 2010 Aug 1. PMID:20678931 doi:10.1016/j.bmcl.2010.07.014
