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| ===Pharmacokinetics=== | | ===Pharmacokinetics=== |
| {| class="wikitable" border="1" width="40%" style="text-align:center"
| | <table style="background: cellspacing="0px" align="" cellpadding="0px" width="42%"> |
| |-
| | <tr> |
| ! colspan="6" align="center"| Glitazone [[Pharmacokinetics]] Comparison at Equivalent Dosages <ref>doi: 10.1111/j.1365-2125.2007.02986.x</ref><ref>PMID:18997160</ref><ref>PMID: 9454824</ref><ref>PMID: 17594391</ref>
| | <td style="width:100%; vertical-align:top;border-width:0px; border-style:inset"> |
| |-
| | <div style="height:100%; width: 100%"> |
| ! Parameter
| | {{:Glitazone Pharmacokinetics}} |
| ! [[Pioglitazone]] (Actos)
| | </div> |
| ! [[Rosiglitazone]] (Avandia)
| | </td> |
| | | </tr> |
| |-
| | </table> |
| ! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
| |
| ! 1.8
| |
| ! 1
| |
| | |
| |-
| |
| ! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
| |
| ! 617
| |
| ! 361
| |
| |-
| |
| ! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
| |
| ! 83
| |
| ! 99
| |
| |-
| |
| ! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
| |
| ! 99
| |
| ! 99
| |
| |-
| |
| ! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
| |
| ! 3-8
| |
| ! 3-4
| |
| |-
| |
| ! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
| |
| ! 6244
| |
| ! 2024
| |
| |-
| |
| ! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
| |
| ! 360
| |
| ! 10
| |
| |-
| |
| ! Equivalent Dosage (mg)
| |
| ! 30
| |
| ! 4
| |
| |-
| |
| ! Metabolism
| |
| ! Hepatic <br/>(CYP2C8)
| |
| ! Hepatic <br/>(CYP2C8)
| |
| |}
| |
|
| |
|
| ===References=== | | ===References=== |
