Cytochrome P450

File:2f9q.png

Crystal Structure of Cytochrome P450 2f9q

Cytochrome P450 (CYP) catalyzes the oxidation of organic substances like lipids. The CYP contains a heme cofactor. The protein is numbered by its gene. CYP-cam catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase CYP. The images at the left and at the right correspond to one representative CYP, i.e. the crystal structure of human CYP2 (2f9q).

3D Structures of Cytochrome P450

CYP/P450 reductase

3kx3, 3kx4, 3kx5, 3hf2, 3dgi, 3cbd, 2nnb, 1zo4, 2yqo, 2yqp, 1smi, 1p0v, 1p0w, 1p0x, 1jme – BmCYP102A1/P450 reductase (mutant) – Bacilus megaterium
1zo9 - BmCYP102A1/P450 reductase+N-palmitoylmethionine
1zoa, 1jpz - BmCYP102A1/P450 reductase (mutant)+N-palmitoylglycine
1smj - BmCYP102A1/P450 reductase (mutant)+N-palmitoleate

human CYP1 family

2hi4 – hCYP1A2+naphthoflavone - human

human CYP2 family

3gph, 3koh, 3lc4 – hCYP2E1 fragment +imidazole derivative
3e6i – hCYP2E1 fragment+indazole
3ebs – hCYP2A6 (mutant)+phenacetin
2fdu, 2fdv, 2fdw, 2fdy - hCYP2A6+pyridine derivative
3e4e – hCYP2E1 fragment+methylpyrazole
3czh, 3dl9, 3c6g – hCYP2R1+vitamin D
2nnh – hCYP2C8+retinoic acid
2nni - hCYP2C8+montelukast
2nnj - hCYP2C8+felodipine
1pq2 - hCYP2C8
1og2, 1og5 – hCYP2C9 (mutant)
1r9o – hCYP2C9 (mutant)+flurbiprofen
2pg5, 2pg6, 2pg7 – hCYP2A6 (mutant)
2p85 – hCYP2A13 (mutant)+indole
3ibd – hCYP2B6 (mutant)+4-(4-chlorophenyl)imidazole
2f9q – hCYP2D6
2z10 – hCYP2A6+coumarin
1z11 - hCYP2A6+methoxalen

human CYP3 family

2v0m – hCYP3A4+ketoconazole
2j0d - hCYP3A4+erythromycin
1tqn, 1w0e, 1w0f, 1w0g – hCYP3A4

human CYP7 family

3dax – hCYP7A1

human CYP19 family

3eqm - hCYP19A1+androstenedione

human CYP46 family

2q9f – hCYP46A1+cholesterol
2q9d - hCYP46A1
2vn0 – hCYP105A1+troglitazone
2zby - hCYP105A1 (mutant)

CYP from Mycobacterium tuberculosis

2vku, 1h5z – MtCYP51 - Mycobacterium tuberculosis
2ci0, 2cib, 1u13 - MtCYP51 (mutant)
1x8v - MtCYP51 (mutant)+estriol
1ea1 - MtCYP51 (mutant)+ fluconazole
1e9x - MtCYP51 (mutant)+ phenylimidazole
3cxv, 3cxx, 3cxy, 3cxz, 3cy0, 3cy1 - MtCYP121 (mutant)
3g5f, 3g5h, 2ij5, 1n40 – MtCYP121
2ij7 - MtCYP121+fluconazole
1n4g - MtCYP121+iodopyrazole
3ivi, 3iw0 – MtCYP125
3iw1 - MtCYP125+androstenedione
3iw2 - MtCYP125+econazole
2uvn - MtCYP130+econazole
2wgy – MtCYP130 (mutant)
2w09, 2w0b, 2w0a - MtCYP130 (mutant)+pyridine inhibitor
2uuq – MtCYP130

CYP-cam

2qbl, 2qbm, 2qbn, 2gqx, 2gr6, 2frz, 2h7s, 6cp4, 2cp4, 3cp4, 4cp4 – PpCYP-cam (mutant) – Pseudomona putida
1dz4, 1dz8, 1dz6, 1dz9, 5cp4, 1phc, 2cpp - PpCYP-cam
2qbo - PpCYP-cam (mutant)+cyanide
1qmq - PpCYP-cam (mutant)+Ru substrate
2h7q - PpCYP-cam+imidazole
1cp4 - PpCYP-cam+benzene
1akd - PpCYP-cam+1S-camphor
2fe6, 2fer, 2feu - PpCYP-cam+Mn protoporphyrin IX
1uyu - PpCYP-cam + Xe
1o76 - PpCYP-cam +cyanide
4cpp - PpCYP-cam+adamantine
5cpp - PpCYP-cam+adamantanone
6cpp - PpCYP-cam+camphene
7cpp - PpCYP-cam+norcamphor
8cpp - PpCYP-cam+thiocamphor
3cpp - PpCYP-cam+CO
1pha, 1phb, 1phd, 1phe, 1phf, 1phg - PpCYP-cam+imidazole derivative
1gek, 1gem - PpCYP-cam +N-butyl-isocyanide
1lwl - PpCYP-cam +fluorescent probe
2h7r - PpCYP-cam (mutant)+imidazole
1k2o - PpCYP-cam (mutant)+pyridine derivative
1gjm - PpCYP-cam (mutant)+sulphydryl reagent
2a1m, 2a1n, 2a10 - PpCYP-cam (mutant)+ferrous dioxygen
1t85, 1t86, 1t87, 1t88 - PpCYP-cam (mutant)+ferrous CO

P450nor

1cl6, 1rom – FoP450nor - Fusarium oxysporum
2rom - FoP450nor+CO
1cmj, 1cmn - FoP450nor (mutant)
1xqd – FoP450nor+pyridinealdehyde adenine
1jfb, 1jfc, 1ged - FoP450nor
1gej, 1gei - FoP450nor+N-butyl-isocyanide
1ulw - FoP450nor (mutant)

rabbit CYP

2bdm – rCYP2B4 – rabbit
1po5 - rCYP2B4 (mutant)
1suo - rCYP2B4 (mutant)+imidazole
1dt6 - rCYP2C5 (mutant)
1nr6 – rCYP2C5+diclofenac
1n6b - rCYP2C5+sulfaphenazole

Other CYPs

1ued – AoCYP oxyC – Amycolatopsis orientalis
1lfk, 1lg9, 1lgf - AoCYP oxyB
1q5d – ScCYPEPOK+epothilone – Sorangium cellulosum
1q5e - ScCYPEPOK
1io8 – SsCYP119 (mutant) – Sulfolobus solfataricus
1io9, 1io7, 1f4u - SsCYP119
1f4t - SsCYP119+ phenylimidazole
1cpt – CYP108 – Pseudomonas sp.
2uwh - BmCYP102+palmitic acid
3ekb, 3ekd, 3ekf, 2ij3, 2ij4 - BmCYP102 heme domain (mutant)
2ij2, 2hpd - BmCYP102 heme domain
3ben - BmCYP102 + imidazole derivative
2j1m, 2j4s - BmCYP102+DMSO
1bvy, 1bu7 – BmCYP102A1 FMN domain
1fag – BmCYP102A1+ palmitic acid
1fah – BmCYP102A1 (mutant)
2bmh - BmCYP102A1
3aba – SaCYP105P1+filipin I – Streptomyces avermitilis
3abb – SaCYP105D6
3e5j, 3e5l - SaCYP105P1 (mutant)
3e5k - SaCYP105P1 (mutant)+4-phenylimidazole
2whw, 2wi9, 2vz7 – SvCYP107L1 (mutant) – Streptomyces venezuelae
2vzm – SvCYP107L1 (mutant)+narbomycin
2c7x - SvCYP107L1+narbomycin
2cd8, 2ca0, 2c6h – SvCYP107L1+YC-17
2bvj - SvCYP107L1
2zqj – BsCYP152A1 – Bacillus subtilis
2zqx - BsCYP152A1+heptanoic acid
1izo – BsCYP BS beta+ palmitoleic acid
1jin, 1jip - SeCYP107A1+ ketoconazole - Saccharopolyspora erythraea
1jio, 1oxa - SeCYP107A1+6DEB
1eup – SeCYP107A1+androstendione
1egy - SeCYP107A1+aminophenanthrene
2jjn, 2jjo - SeCYP113A1 (mutant)
2jjp - SeCYP113A1 (mutant)+ketoconazole
2vrv - SeCYP113A1 (mutant)+clotrimazole
3a1l – SsCYP245A1+dichlorochrompyrrolic acid – Streptomyces sp.
2z3t - SsCYP245A1
2z3u - SsCYP245A1+chromopyrrolic acid
3g5n, 3g93 – rCYP2B4 (mutant)+1-biphenyl-4-methyl-1H-imidazole – rabbit
2q6n – rCYP2B4 (mutant)+chlorophenyl-imidazole
3cv8 – SgCYP105A1 (mutant) – Streptomyces griseolus
3cv9, 2zbz - SgCYP105A1 (mutant)+vitamin D3
2zbx - SgCYP105A1+imidazole
3dam, 3dan, 3dbm – CYP74A2 – Parthenium argentatum
2rch, 3dsi – AtCYP74A+13(S)-HOD – Arabidopsis thaliana
3dsj - AtCYP74A (mutant)+13(S)-HOD
2rcl - AtCYP74A+vernolic acid
3dsk - AtCYP74A (mutant)+ vernolic acid
2rcm, 3cli - AtCYP74A
2rfb – PtCYP – Picrophilus torridus
2rfc – PtCYP+phenylimidazole 2nz5, 2nza, 2dkk – ScCYP158A1 – Streptomyces coelicolor
1gwi - ScCYP154C1
1wiy – TtCYP – Thermus thermophilus
1n97 – TtCYP175A1

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Joel L. Sussman, Michal Harel