3nsj: Difference between revisions
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{{STRUCTURE_3nsj| PDB=3nsj | SCENE= }} | {{STRUCTURE_3nsj| PDB=3nsj | SCENE= }} | ||
===The X-ray crystal structure of lymphocyte perforin=== | ===The X-ray crystal structure of lymphocyte perforin=== | ||
{{ABSTRACT_PUBMED_21037563}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3nsj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSJ OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021037563</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Caradoc-Davies, T T.]] | [[Category: Caradoc-Davies, T T.]] | ||
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[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Pore forming protein]] | [[Category: Pore forming protein]] | ||