2jsd: Difference between revisions

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==Overview==

The solution structure of the catalytic domain of MMP-20, a member of the, matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic, acid (NNGH), is here reported and compared with other MMPs-NNGH adducts., The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present, structure experiences specific structural and dynamical similarities with, some MMPs and differences with others, around the catalytic cavity. The, present solution structure, not only contributes to fill the gap of, structural knowledge on human MMPs, but also provides further information, to design more selective and efficient inhibitors for a specific member of, this class of proteins.

The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins.

==About this Structure==

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[[Category: Bertini, I.]]

[[Category: Cantini, F.]]

[[Category: Conte, R.Del.]]

[[Category: Conte, R Del.]]

[[Category: Cozzi, R.]]

[[Category: Gonnelli, L.]]

[[Category: SPINE, Structural.Proteomics.in.Europe.]]

[[Category: SPINE, Structural Proteomics in Europe.]]

[[Category: CA]]

[[Category: NGH]]

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[[Category: structural proteomics in europe]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:05:38 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The solution structure of the catalytic domain of MMP-20, a member of the, matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic, acid (NNGH), is here reported and compared with other MMPs-NNGH adducts., The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present, structure experiences specific structural and dynamical similarities with, some MMPs and differences with others, around the catalytic cavity. The, present solution structure, not only contributes to fill the gap of, structural knowledge on human MMPs, but also provides further information, to design more selective and efficient inhibitors for a specific member of, this class of proteins.
+The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been characterized as well. We have found that, despite the same fold and very high overall similarity, the present structure experiences specific structural and dynamical similarities with some MMPs and differences with others, around the catalytic cavity. The present solution structure, not only contributes to fill the gap of structural knowledge on human MMPs, but also provides further information to design more selective and efficient inhibitors for a specific member of this class of proteins.
 ==About this Structure==
@@ Line 17: / Line 17: @@
 [[Category: Bertini, I.]]
 [[Category: Cantini, F.]]
-[[Category: Conte, R.Del.]]
+[[Category: Conte, R Del.]]
 [[Category: Cozzi, R.]]
 [[Category: Gonnelli, L.]]
-[[Category: SPINE, Structural.Proteomics.in.Europe.]]
+[[Category: SPINE, Structural Proteomics in Europe.]]
 [[Category: CA]]
 [[Category: NGH]]
@@ Line 32: / Line 32: @@
 [[Category: structural proteomics in europe]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:08:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:05:38 2008''