Spectrin

File:3lbx.png

Crystal Structure of Spectrin 3lbx

Spectrin forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of alpha1 and beta1 monomers. In invertebrates there are SPT alpha, beta and betaH. In vertebrates there are SPT alpha1 (SPTA1), alpha2 (SPTA2) and beta1 (SPTB1) to beta5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. The images at the left and at the right correspond to one representative Spectrin, i.e. the crystal structure of human Spectrin (3lbx).

3D Structures of Spectrin

SPTA1

3lbx – hSPTA1+hSPTB1 – human 3i9q, 2rot, 2pqh, 2oaw, 2nuz, 1u06 - cSPTA1 SH3 domain – chicken 2jm8, 2jm9, 2cdt, 2f2v, 2f2w, 2f2x - cSPTA1 SH3 domain (mutant) 2jma, 2jmc - cSPTA1 SH3 domain (mutant)+P41 peptide 2rmo, 1neg, 1m8m - cSPTA1 SH3 domain – NMR

SPTA2

3f31 – hSPTA2 tetramerization domain 1qkw – cSPTA2 SH3 domain (mutant) 2fot - SPTA2+calmodulin – Bos taurus 3fb2 – hSPTA2 repeats 15-16

SPTA

1uue, 1e7o, 1g2b, 1aey, 1tuc, 1tud - cSPTA SH3 domain (mutant) – NMR 1e6g, 1e6h, 1hd3, 1qkx, 1pwt, 1bk2, 1shg - cSPTA SH3 domain (mutant) 1u4q – cSPTA repeats 15-17 1u5p - cSPTA repeats 15-16 1cun - cSPTA repeats 16-17 1aj3 - cSPTA repeat 16 - NMR 1owa - hSPTA tetramerization domain – NMR 1qkw – cSPTA2 SH3 domain (mutant) 2fot - SPTA2+calmodulin – Bos taurus

SPTB1

3bkt, 3kbu - hSPTB1+ankyrin 3f57, 3edu - hSPTB1 ankyrin binding domain 1s35 – hSPTB1 repeats 8-9

SPTB2

3edv – hSPTB2 repeats 14-16

SPTB3

1wyq – hSPTB3 CH domain – NMR 1wjm – hSPTB3 – NMR

SPTB

1bkr, 1aa2 – hSPTB CH domain 1mph – SPTB Pleckstrin Homology domain – NMR 1dro - mSPTB PH domain – NMR – mouse 1btn – mSPTB+inositol phosphate 2spc – SPT fragment - Drosophila

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel