Troponin: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of Troponin [[1yv0]] {{STRUCTURE_1yv0| PDB=1yv0 | SIZE=300| SCENE= |right|CAPTION=Troponin 1yv0 }} Troponin (Tn) is a regul...
 
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[[Image:1yv0.png|left|200px|thumb|Crystal Structure of Troponin [[1yv0]]]]
[[Image:1yv0.png|left|200px|thumb|Crystal Structure of Troponin [[1yv0]]]]
{{STRUCTURE_1yv0|  PDB=1yv0  | SIZE=300| SCENE= |right|CAPTION=Troponin [[1yv0]] }}
{{STRUCTURE_1yv0|  PDB=1yv0  | SIZE=300| SCENE=Troponin/Cv/1 |right|CAPTION=Troponin [[1yv0]] }}


[[Troponin]] (Tn) is a regulatory protein in muscle contraction.  It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions.  TnT binds to [[Tropomyosin|tropomyosin]] and TnI binds to actin which is found in thin muscle filaments. The images at the left and at the right correspond to one representative Tn, ''i.e.'' the crystal structure of Troponin C + Troponin I + Troponin T of chicken ([[1yv0]]).
[[Troponin]] (Tn) is a regulatory protein in muscle contraction.  It contains 3 subunits: TnC causes conformational change in TnI when it binds to calcium ions.  TnT binds to [[Tropomyosin|tropomyosin]] and TnI binds to actin which is found in thin muscle filaments. The images at the left and at the right correspond to one representative Tn, ''i.e.'' the crystal structure of complex Troponin C/Troponin I/Troponin T ([[1yv0]]).


{{TOC limit|limit=2}}
{{TOC limit|limit=2}}
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=== Troponin C+Troponin I+Troponin T ===


Troponin C+Troponin I+Troponin T
[[2w49]] – cTnC+cTnI+cTnT+tropomyosin+actin – chicken<br />
[[1ytz]] - cTnC+cTnI+cTnT+Ca++<br />
[[1yv0]] - cTnC+cTnI+cTnT<br />
[[1j1d]], [[1j1e]] – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human


2w49 – cTnC+cTnI+cTnT+tropomyosin+actin – chicken
1ytz - cTnC+cTnI+cTnT+Ca++
1yv0 - cTnC+cTnI+cTnT
1j1d, 1j1e – hTnC (mutant)+hTnI (mutant) fragment+hTnT fragment+Ca++ - human


Troponin C+Troponin I
=== Troponin C+Troponin I ===


2krd – hTnC+hTnI  – NMR
[[2krd]] – hTnC+hTnI  – NMR<br />
1ozs - hTnC C-terminal+hTnI N-terminal – NMR
[[1ozs]] - hTnC C-terminal+hTnI N-terminal – NMR<br />
1lxf, 1mxl - hTnC N-terminal+hTnI fragment
[[1lxf]], [[1mxl]] - hTnC N-terminal+hTnI fragment<br />
2kgb – hTnC (mutant) regulatory domain+TnI
[[2kgb]] – [[hTnC]] (mutant) regulatory domain+TnI<br />
1sbj – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR
[[1sbj]] – cTnC C-terminal+cTnI N-terminal+Mg++ - NMR<br />
1scv, 1fi5, 1blq - cTnC C-terminal+cTnI N-terminal – NMR
[[1scv]], [[1fi5]], [[1blq]] - cTnC C-terminal+cTnI N-terminal – NMR<br />
1npq - cTnC (mutant) N-terminal+cTnI  fragment+rhodamine
[[1npq]] - cTnC (mutant) N-terminal+cTnI  fragment+rhodamine<br />
1jc2 - cTnC C-terminal+cTnI N-terminal
[[1jc]]2 - cTnC C-terminal+cTnI N-terminal<br />
1a2x - rTnC +rTnI fragment – rabbit
[[1a2x]] - rTnC +rTnI fragment – rabbit


Troponin C


2kdh – hTnC+green tea polyphenol – NMR
=== Troponin C ===
2kfx – hTnC (mutant) N-terminal+Ca+naphthalene derivative
2jt0, 2jtz, 2jt8, 2jt3 – hTnC (mutant) – NMR
2jxl - hTnC (mutant) N-terminal – NMR
1wrk, 1wrl - hTnC (mutant) N-terminal+trifluoperazine
1spy - hTnC  N-terminal– NMR
1ih0 - hTnC C-terminal+EMD 57033 – NMR
1ap4 - hTnC N-terminal+Ca++ – NMR
1la0, 4tnc – cTnC+Ca++
1dtl – cTnC (mutant)+Ca++ +bepridil
1skt, 1zac, 2ctn- cTnC N-terminal – NMR
1aj4 - cTnC (mutant) +Ca++ – NMR
1ctn - cTnC C-terminal – NMR
1avs - cTnC N-terminal+Ca++
1smg, 1tnq - cTnC N-terminal+Ca++ - NMR
1ncy – cTnC+Mn++
1ncx, 1ncz, 1top – cTnC
1pon, 1cta, 1ctd – cTnC fragment – NMR
1tnp - cTnC N-terminal – NMR
1tnw, 1tnx - cTnC +Ca++ - NMR
1trf - tTnC N-terminal+Ca++ - turkey – NMR
5tnc - tTnC
2k2a - TnC  C-terminal – Lethocerus indicus – NMR
2jnf – TnC – fly – NMR
1r2u, 1r6p - TnC  N-terminal – trout – NMR
1tcf – rTnC+Ca++
1tn4, 2tn4 – rTnC (mutant)+Ca++


Troponin I
[[2kdh]] – hTnC+green tea polyphenol – NMR<br />
2jpw – TnI biphosphorylated – mouse – NMR
[[2kfx]] – hTnC (mutant) N-terminal+Ca+naphthalene derivative<br />
1vdi – cTnI – NMR
[[2jt0]], [[2jtz]], [[2jt8]], [[2jt3]] – hTnC (mutant) – NMR<br />
1vdj – cTnI+Ca++ - NMR
[[2jxl]] - hTnC (mutant) N-terminal – NMR<br />
[[1wrk]], [[1wrl]] - hTnC (mutant) N-terminal+trifluoperazine<br />
[[1spy]] - hTnC  N-terminal– NMR<br />
[[1ih0]] - hTnC C-terminal+EMD 57033 – NMR<br />
[[1ap4]] - hTnC N-terminal+Ca++ – NMR<br />
[[1la0]], [[4tnc]] – cTnC+Ca++<br />
[[1dtl]] – cTnC (mutant)+Ca++ +bepridil<br />
[[1skt]], [[1zac]], [[2ctn]] - cTnC N-terminal – NMR<br />
[[1aj4]] - cTnC (mutant) +Ca++ – NMR<br />
[[1ctn]] - cTnC C-terminal – NMR<br />
[[1avs]] - cTnC N-terminal+Ca++<br />
[[1smg]], [[1tnq]] - cTnC N-terminal+Ca++ - NMR<br />
[[1ncy]] – cTnC+Mn++<br />
[[1ncx]], [[1ncz]], [[1top]] – cTnC<br />
[[1pon]], [[1cta]], [[1ctd]] – cTnC fragment – NMR<br />
[[1tnp]] - cTnC N-terminal – NMR<br />
[[1tnw]], [[1tnx]] - cTnC +Ca++ - NMR<br />
[[1trf]] - tTnC N-terminal+Ca++ - turkey – NMR<br />
[[5tnc]] - tTnC<br />
[[2k2a]] - TnC  C-terminal – ''Lethocerus indicus'' – NMR<br />
[[2jnf]] – TnC – fly – NMR<br />
[[1r2u]], [[1r6p]] - TnC  N-terminal – trout – NMR<br />
[[1tcf]] – rTnC+Ca++<br />
[[1tn4]], [[2tn4]] – rTnC (mutant)+Ca++


Troponin T


2z5h – yTnT fragment+tropomyosin – yeast
=== Troponin I ===
 
[[2jpw]] – TnI biphosphorylated – mouse – NMR<br />
[[1vdi]] – cTnI – NMR<br />
[[1vdj]] – cTnI+Ca++ - NMR
 
 
=== Troponin T ===
 
[[2z5h]] – yTnT fragment+tropomyosin – yeast
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