3nup: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,501 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,501 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3nup.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3nup", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3nup|  PDB=3nup  |  SCENE=  }}  
{{STRUCTURE_3nup|  PDB=3nup  |  SCENE=  }}  
===CDK6 (monomeric) in complex with inhibitor===
===CDK6 (monomeric) in complex with inhibitor===
{{ABSTRACT_PUBMED_21038853}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/CDK6_HUMAN CDK6_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.<ref>PMID:8114739</ref> <ref>PMID:12833137</ref> <ref>PMID:14985467</ref> <ref>PMID:15254224</ref> <ref>PMID:15809340</ref> <ref>PMID:17431401</ref> <ref>PMID:17420273</ref> <ref>PMID:20668294</ref> <ref>PMID:20333249</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_21038853}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21038853 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_21038853}}


==About this Structure==
==About this Structure==
3NUP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NUP OCA].  
[[3nup]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NUP OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:21038853</ref><references group="xtra"/>
<ref group="xtra">PMID:021038853</ref><references group="xtra"/><references/>
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 32: Line 19:
[[Category: Protein kinase]]
[[Category: Protein kinase]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Transferase-transferase inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:55:13 2010''
Retrieved from "https://proteopedia.org/3nup"