Reverse transcriptase: Difference between revisions
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<applet size='[450,338]' frame='true' align='right' name='Reverse Transcriptase scene='Reverse_transcriptase/Presentation/3' caption='The hand-like two-enzymes-in-one protein that amazingly makes DNA from RNA' /> | <applet size='[450,338]' frame='true' align='right' name='Reverse Transcriptase scene='Reverse_transcriptase/Presentation/3' caption='The hand-like two-enzymes-in-one protein that amazingly makes DNA from RNA' /> | ||
This ''hand-like'' <scene name='Reverse_transcriptase/Chains/2'>heterodimer</scene> protein that has an usual length of 1000 residues (560 in Chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets, showing α+β <scene name='Reverse_transcriptase/Secondary/2'>secondary structure</scene> domains; <scene name='Reverse_transcriptase/Chaina/2'>Chain A</scene> has an usual weight of 66KDa whereas <scene name='Reverse_transcriptase/Chainb/2'>Chain B</scene> is around 51KDa, those monomers are derived from the same gen but p51 lacks the aminoacids of one active site and has a different tertiary structure conformation compared with p66, for this reason is totally inactive. | This ''hand-like'' <scene name='Reverse_transcriptase/Chains/2'>heterodimer</scene> protein that has an usual length of 1000 residues (560 in Chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets, showing α+β <scene name='Reverse_transcriptase/Secondary/2'>secondary structure</scene> domains; <scene name='Reverse_transcriptase/Chaina/2'>Chain A</scene> has an usual weight of 66KDa whereas <scene name='Reverse_transcriptase/Chainb/2'>Chain B</scene> is around 51KDa, those monomers are derived from the same gen but p51 lacks the aminoacids of one active site and has a different tertiary structure conformation compared with p66, for this reason is totally inactive. <ref>PMID: 1377403</ref> <!-- [http://www.sciencemag.org.silk.library.umass.edu:2048/cgi/content/abstract/sci;256/5065/1783?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&volume=256&firstpage=1783&resourcetype=HWCIT] --> | ||
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==References== | ==References== | ||
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*[2] Consurf Server Data Base. Evolutionary conservation profile for Reverse Transcriptase PDB file 1JLB <!--accessed November 28, 2009--> | *[2] Consurf Server Data Base. Evolutionary conservation profile for Reverse Transcriptase PDB file 1JLB <!--accessed November 28, 2009--> | ||
*[3] Abbondanzieri, E.A. ''et al''. Nature 453, 184-189 (2008) | [http://dx.doi.org/10.1038/nature06941 doi:10.1038/nature06941] | *[3] Abbondanzieri, E.A. ''et al''. Nature 453, 184-189 (2008) | [http://dx.doi.org/10.1038/nature06941 doi:10.1038/nature06941] | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
