2uua: Difference between revisions

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==Overview==

One of the most prevalent base modifications involved in decoding is, uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known, for several decades that this modification enables a single tRNA to decode, all four codons in a degenerate codon box. We have determined structures, of an anticodon stem-loop of tRNA(Val) containing the modified uridine, with all four valine codons in the decoding site of the 30S ribosomal, subunit. An intramolecular hydrogen bond involving the modification helps, to prestructure the anticodon loop. We found unusual base pairs with the, three noncomplementary codon bases, including a G.U base pair in standard, Watson-Crick geometry, which presumably involves an enol form for the, uridine. These structures suggest how a modification in the uridine at the, wobble position can expand the decoding capability of a tRNA.

One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA.

==About this Structure==

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[[Category: Protein complex]]

[[Category: Thermus thermophilus]]

[[Category: Agris, P.F.]]

[[Category: Agris, P F.]]

[[Category: Dziergowska, A.]]

[[Category: Malkiewicz, A.]]

[[Category: Murphy, F.V.]]

[[Category: Murphy, F V.]]

[[Category: Ramakrishnan, V.]]

[[Category: Vendeix, F.A.P.]]

[[Category: Vendeix, F A.P.]]

[[Category: Weixlbaumer, A.]]

[[Category: K]]

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[[Category: zinc-finger]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:50:18 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-One of the most prevalent base modifications involved in decoding is, uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known, for several decades that this modification enables a single tRNA to decode, all four codons in a degenerate codon box. We have determined structures, of an anticodon stem-loop of tRNA(Val) containing the modified uridine, with all four valine codons in the decoding site of the 30S ribosomal, subunit. An intramolecular hydrogen bond involving the modification helps, to prestructure the anticodon loop. We found unusual base pairs with the, three noncomplementary codon bases, including a G.U base pair in standard, Watson-Crick geometry, which presumably involves an enol form for the, uridine. These structures suggest how a modification in the uridine at the, wobble position can expand the decoding capability of a tRNA.
+One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Protein complex]]
 [[Category: Thermus thermophilus]]
-[[Category: Agris, P.F.]]
+[[Category: Agris, P F.]]
 [[Category: Dziergowska, A.]]
 [[Category: Malkiewicz, A.]]
-[[Category: Murphy, F.V.]]
+[[Category: Murphy, F V.]]
 [[Category: Ramakrishnan, V.]]
-[[Category: Vendeix, F.A.P.]]
+[[Category: Vendeix, F A.P.]]
 [[Category: Weixlbaumer, A.]]
 [[Category: K]]
@@ Line 41: / Line 41: @@
 [[Category: zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:20:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:50:18 2008''