2r6a: Difference between revisions

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==Overview==

The complex between the DnaB helicase and the DnaG primase unwinds duplex, DNA at the eubacterial replication fork and synthesizes the Okazaki RNA, primers. The crystal structures of hexameric DnaB and its complex with the, helicase binding domain (HBD) of DnaG reveal that within the hexamer the, two domains of DnaB pack with strikingly different symmetries to form a, distinct two-layered ring structure. Each of three bound HBDs stabilizes, the DnaB hexamer in a conformation that may increase its processivity., Three positive, conserved electrostatic patches on the N-terminal domain, of DnaB may also serve as a binding site for DNA and thereby guide the DNA, to a DnaG active site.

The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.

==About this Structure==

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[[Category: Protein complex]]

[[Category: Bailey, S.]]

[[Category: Eliason, W.K.]]

[[Category: Eliason, W K.]]

[[Category: Steitz, T.A.]]

[[Category: Steitz, T A.]]

[[Category: SO4]]

[[Category: dnab]]

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[[Category: replication]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 12~~:24:14 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:44:55 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The complex between the DnaB helicase and the DnaG primase unwinds duplex, DNA at the eubacterial replication fork and synthesizes the Okazaki RNA, primers. The crystal structures of hexameric DnaB and its complex with the, helicase binding domain (HBD) of DnaG reveal that within the hexamer the, two domains of DnaB pack with strikingly different symmetries to form a, distinct two-layered ring structure. Each of three bound HBDs stabilizes, the DnaB hexamer in a conformation that may increase its processivity., Three positive, conserved electrostatic patches on the N-terminal domain, of DnaB may also serve as a binding site for DNA and thereby guide the DNA, to a DnaG active site.
+The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes the Okazaki RNA primers. The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two-layered ring structure. Each of three bound HBDs stabilizes the DnaB hexamer in a conformation that may increase its processivity. Three positive, conserved electrostatic patches on the N-terminal domain of DnaB may also serve as a binding site for DNA and thereby guide the DNA to a DnaG active site.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Protein complex]]
 [[Category: Bailey, S.]]
-[[Category: Eliason, W.K.]]
+[[Category: Eliason, W K.]]
-[[Category: Steitz, T.A.]]
+[[Category: Steitz, T A.]]
 [[Category: SO4]]
 [[Category: dnab]]
@@ Line 23: / Line 23: @@
 [[Category: replication]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:24:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:44:55 2008''