2irw: Difference between revisions

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==Overview==

A novel class of adamantane ethers 11beta-hydroxysteroid hydrogenase type, I inhibitors has been discovered. These compounds have excellent HSD-1, potency and selectivity against HSD-2. The structure-activity, relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1, are discussed.

A novel class of adamantane ethers 11beta-hydroxysteroid hydrogenase type I inhibitors has been discovered. These compounds have excellent HSD-1 potency and selectivity against HSD-2. The structure-activity relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1 are discussed.

==Disease==

Known diseases associated with this structure: Cortisone reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600713 600713]]

==About this Structure==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Longenecker, K.L.]]

[[Category: Longenecker, K L.]]

[[Category: Patel, J.R]]

[[Category: Patel, J R]]

[[Category: Qin, W.]]

[[Category: Russell, J.]]

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[[Category: oxidoreductase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 12~~:32:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:55:21 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-A novel class of adamantane ethers 11beta-hydroxysteroid hydrogenase type, I inhibitors has been discovered. These compounds have excellent HSD-1, potency and selectivity against HSD-2. The structure-activity, relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1, are discussed.
+A novel class of adamantane ethers 11beta-hydroxysteroid hydrogenase type I inhibitors has been discovered. These compounds have excellent HSD-1 potency and selectivity against HSD-2. The structure-activity relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1 are discussed.
+==Disease==
+Known diseases associated with this structure: Cortisone reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600713 600713]]
 ==About this Structure==
@@ Line 14: / Line 17: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Longenecker, K.L.]]
+[[Category: Longenecker, K L.]]
-[[Category: Patel, J.R]]
+[[Category: Patel, J R]]
 [[Category: Qin, W.]]
 [[Category: Russell, J.]]
@@ Line 25: / Line 28: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:32:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:55:21 2008''