2qu4: Difference between revisions
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New page: left|200px<br /><applet load="2qu4" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qu4" /> '''Model for Bacterial ParM Filament'''<br /> ... |
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==Overview== | ==Overview== | ||
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving | Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Egelman, E | [[Category: Egelman, E H.]] | ||
[[Category: Galkin, V | [[Category: Galkin, V E.]] | ||
[[Category: Garner, E | [[Category: Garner, E C.]] | ||
[[Category: Heuser, J.]] | [[Category: Heuser, J.]] | ||
[[Category: Mullins, R | [[Category: Mullins, R D.]] | ||
[[Category: Orlova, A.]] | [[Category: Orlova, A.]] | ||
[[Category: actin-like protein]] | [[Category: actin-like protein]] | ||
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[[Category: structural protein]] | [[Category: structural protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:42:15 2008'' | ||
