3is9: Difference between revisions

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[[Image:3is9.png|left|200px]]
[[Image:3is9.png|left|200px]]


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{{STRUCTURE_3is9|  PDB=3is9  |  SCENE=  }}  
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===Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).===
===Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).===


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{{ABSTRACT_PUBMED_19775161}}
{{ABSTRACT_PUBMED_19775161}}


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==See Also==
==See Also==
*[[Reverse transcriptase]]
*[[Reverse transcriptase|Reverse transcriptase]]


==Reference==
==Reference==
<ref group="xtra">PMID:19775161</ref><references group="xtra"/>
<ref group="xtra">PMID:019775161</ref><references group="xtra"/>
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: Arnold, E.]]
[[Category: Arnold, E.]]
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[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Cytoplasm]]
[[Category: Dna integration]]
[[Category: Dna integration]]
[[Category: Dna recombination]]
[[Category: Dna recombination]]
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[[Category: Viral nucleoprotein]]
[[Category: Viral nucleoprotein]]
[[Category: Virion]]
[[Category: Virion]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]

Revision as of 03:55, 26 July 2012

File:3is9.png

Template:STRUCTURE 3is9

Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).

Template:ABSTRACT PUBMED 19775161

About this Structure

3is9 is a 2 chain structure of Reverse transcriptase with sequence from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

See Also

Reference

  1. Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. J Med Chem. 2009 Oct 22;52(20):6467-73. PMID:19775161 doi:10.1021/jm901167t

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