2ph0: Difference between revisions

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==Overview==

We report here the crystal structure at 2.0 A resolution of the, AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium, tumefaciens. The protein is a tightly associated dimer, each subunit of, which bears strong structural homology with the two domains of the heme, utilization protein ChuS from Escherichia coli and HemS from Yersinia, enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is, the same as that of the two domains in ChuS and HemS, providing structural, evidence that these two proteins evolved by gene duplication. However, the, binding site for heme, while conserved in HemS and ChuS, is not conserved, in AGR_C_4470p, suggesting that it probably has a different function. This, is supported by the presence of two homologs of AGR_C_4470p in E. coli, in, addition to the ChuS protein.

We report here the crystal structure at 2.0 A resolution of the AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium tumefaciens. The protein is a tightly associated dimer, each subunit of which bears strong structural homology with the two domains of the heme utilization protein ChuS from Escherichia coli and HemS from Yersinia enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is the same as that of the two domains in ChuS and HemS, providing structural evidence that these two proteins evolved by gene duplication. However, the binding site for heme, while conserved in HemS and ChuS, is not conserved in AGR_C_4470p, suggesting that it probably has a different function. This is supported by the presence of two homologs of AGR_C_4470p in E. coli, in addition to the ChuS protein.

==About this Structure==

Line 17:

[[Category: Cunningham, K.]]

[[Category: Fang, Y.]]

[[Category: Hunt, J.F.]]

[[Category: Hunt, J F.]]

[[Category: Ma, L-C.]]

[[Category: Montelione, G.T.]]

[[Category: Montelione, G T.]]

[[Category: NESG, Northeast.Structural.Genomics.Consortium.]]

[[Category: NESG, Northeast Structural Genomics Consortium.]]

[[Category: Neely, H.]]

[[Category: Owens, L.]]

[[Category: Seetharaman, J.]]

[[Category: Tong, L.]]

[[Category: Vorobiev, S.M.]]

[[Category: Vorobiev, S M.]]

[[Category: Xiao, R.]]

[[Category: erwct]]

Line 37:

[[Category: unknown function]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-We report here the crystal structure at 2.0 A resolution of the, AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium, tumefaciens. The protein is a tightly associated dimer, each subunit of, which bears strong structural homology with the two domains of the heme, utilization protein ChuS from Escherichia coli and HemS from Yersinia, enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is, the same as that of the two domains in ChuS and HemS, providing structural, evidence that these two proteins evolved by gene duplication. However, the, binding site for heme, while conserved in HemS and ChuS, is not conserved, in AGR_C_4470p, suggesting that it probably has a different function. This, is supported by the presence of two homologs of AGR_C_4470p in E. coli, in, addition to the ChuS protein.
+We report here the crystal structure at 2.0 A resolution of the AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium tumefaciens. The protein is a tightly associated dimer, each subunit of which bears strong structural homology with the two domains of the heme utilization protein ChuS from Escherichia coli and HemS from Yersinia enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is the same as that of the two domains in ChuS and HemS, providing structural evidence that these two proteins evolved by gene duplication. However, the binding site for heme, while conserved in HemS and ChuS, is not conserved in AGR_C_4470p, suggesting that it probably has a different function. This is supported by the presence of two homologs of AGR_C_4470p in E. coli, in addition to the ChuS protein.
 ==About this Structure==
@@ Line 17: / Line 17: @@
 [[Category: Cunningham, K.]]
 [[Category: Fang, Y.]]
-[[Category: Hunt, J.F.]]
+[[Category: Hunt, J F.]]
 [[Category: Ma, L-C.]]
-[[Category: Montelione, G.T.]]
+[[Category: Montelione, G T.]]
-[[Category: NESG, Northeast.Structural.Genomics.Consortium.]]
+[[Category: NESG, Northeast Structural Genomics Consortium.]]
 [[Category: Neely, H.]]
 [[Category: Owens, L.]]
 [[Category: Seetharaman, J.]]
 [[Category: Tong, L.]]
-[[Category: Vorobiev, S.M.]]
+[[Category: Vorobiev, S M.]]
 [[Category: Xiao, R.]]
 [[Category: erwct]]
@@ Line 37: / Line 37: @@
 [[Category: unknown function]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:56:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:29:20 2008''