3k3q: Difference between revisions

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[[Image:3k3q.png|left|200px]]
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{{STRUCTURE_3k3q|  PDB=3k3q  |  SCENE=  }}  
{{STRUCTURE_3k3q|  PDB=3k3q  |  SCENE=  }}  
===Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain===
===Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain===
{{ABSTRACT_PUBMED_20138889}}


 
==Function==
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[[http://www.uniprot.org/uniprot/BXA1_CLOBH BXA1_CLOBH]] Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure.
The line below this paragraph, {{ABSTRACT_PUBMED_20138889}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20138889}}


==About this Structure==
==About this Structure==
[[3k3q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum_a_str._hall Clostridium botulinum a str. hall] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3Q OCA].  
[[3k3q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum_a_str._hall Clostridium botulinum a str. hall] and [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3Q OCA].  
==See Also==
*[[Llama Antibody Inhibits Botulinum Neruotoxin]]


==Reference==
==Reference==
<ref group="xtra">PMID:20138889</ref><references group="xtra"/>
<ref group="xtra">PMID:020138889</ref><references group="xtra"/><references/>
[[Category: Bontoxilysin]]
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum a str. hall]]
[[Category: Clostridium botulinum a str. hall]]
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[[Category: Cell junction]]
[[Category: Cell junction]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Cytoplasm]]
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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[[Category: Metalloprotease]]
[[Category: Metalloprotease]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
[[Category: Pharmaceutical]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Secreted]]
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Vhh]]
[[Category: Vhh]]
[[Category: Zinc]]
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