3msh: Difference between revisions

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~~[[Image:3msh.png|left|200px]]~~

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===Crystal structure of Hepatitis B X-Interacting Protein at high resolution===

==Function==

[[http://www.uniprot.org/uniprot/HBXIP_HUMAN HBXIP_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Garcia-Saez, I.]]

[[Category: Skoufias, D.]]

[[Category: Alpha-beta protein]]

[[Category: Profilin-like fold]]

[[Category: Protein binding]]

[[Category: Roadblock/lc7 domain superfamily]]

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-[[Image:3msh.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3msh", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3msh|  PDB=3msh  |  SCENE=  }}
 ===Crystal structure of Hepatitis B X-Interacting Protein at high resolution===
+{{ABSTRACT_PUBMED_21059355}}
+==Function==
+[[http://www.uniprot.org/uniprot/HBXIP_HUMAN HBXIP_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref>
 ==About this Structure==
@@ Line 16: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:21059355</ref><references group="xtra"/>
+<ref group="xtra">PMID:021059355</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Garcia-Saez, I.]]
 [[Category: Skoufias, D.]]
+[[Category: Alpha-beta protein]]
+[[Category: Profilin-like fold]]
+[[Category: Protein binding]]
+[[Category: Roadblock/lc7 domain superfamily]]