3pdn: Difference between revisions
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m Protected "3pdn" [edit=sysop:move=sysop] |
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{{STRUCTURE_3pdn| PDB=3pdn | SCENE= }} | {{STRUCTURE_3pdn| PDB=3pdn | SCENE= }} | ||
===Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin=== | ===Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin=== | ||
{{ABSTRACT_PUBMED_21167177}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN]] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref> | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021167177</ref><references group="xtra"/><references/> | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Sirinupong, N.]] | [[Category: Sirinupong, N.]] | ||
[[Category: Yang, Z.]] | [[Category: Yang, Z.]] | ||
[[Category: Methyltransferase]] | |||
[[Category: Rossmann fold]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
[[Category: Zinc finger]] | |||