3puj: Difference between revisions
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{{STRUCTURE_3puj| PDB=3puj | SCENE= }} | {{STRUCTURE_3puj| PDB=3puj | SCENE= }} | ||
===Crystal structure of the MUNC18-1 and SYNTAXIN4 N-Peptide complex=== | ===Crystal structure of the MUNC18-1 and SYNTAXIN4 N-Peptide complex=== | ||
{{ABSTRACT_PUBMED_21193638}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/STXB1_RAT STXB1_RAT]] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. [[http://www.uniprot.org/uniprot/STX4_MOUSE STX4_MOUSE]] Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.<ref>PMID:9045631</ref> <ref>PMID:10394363</ref> <ref>PMID:18827011</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021193638</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Christie, M P.]] | [[Category: Christie, M P.]] | ||
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[[Category: Martin, J L.]] | [[Category: Martin, J L.]] | ||
[[Category: Saez, N J.]] | [[Category: Saez, N J.]] | ||
[[Category: Endocytosis-exocytosis complex]] | |||
[[Category: Membrane trafficking]] | |||
[[Category: Sm protein]] | |||
[[Category: Snare protein]] | |||
[[Category: Syntaxin]] | |||
[[Category: Syntaxin binding protein]] | |||