Colicin: Difference between revisions
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==Targeting and Receptors== | ==Targeting and Receptors== | ||
Colicins vary significantly in the receptors that they target to initiate their uptake. The majority of the group A colicins use the BtuB receptor, which is present on ''E. coli'' as a vitamin B12 uptake receptor. | Colicins vary significantly in the receptors that they target to initiate their uptake. The majority of the group A colicins use the BtuB receptor, which is present on ''E. coli'' as a vitamin B12 uptake receptor. Once bound to the receptor, the coiled-coil receptor binding domain unfolds, in an essential step that removes the immunity protein and triggers translocation. <ref> PMID: 15231784 </ref> | ||
Understanding how the colicins can cross the membrane is highly important, as if this could be targeted and exploited it could be useful for novel therapeutic agents. <ref> PMID: 15044477 </ref> | Understanding how the colicins can cross the membrane is highly important, as if this could be targeted and exploited it could be useful for novel therapeutic agents. <ref> PMID: 15044477 </ref> | ||
