3p5f: Difference between revisions

Line 1:

~~[[Image:3p5f.png|left|200px]]~~

~~<!--~~

~~The line below this paragraph, containing "STRUCTURE_3p5f", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display.~~

~~-->~~

===Structure of the carbohydrate-recognition domain of human Langerin with man2 (Man alpha1-2 Man)===

==Disease==

[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref><ref>PMID:16567809</ref>

~~<!--~~

==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_21112338}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref><ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 21112338~~ is the ~~PubMed ID number~~.

-->

~~{{ABSTRACT_PUBMED_21112338}}~~

==About this Structure==

Line 22:

Line 13:

==Reference==

[[Category: Homo sapiens]]

[[Category: Drickamer, K.]]

Line 32:

Line 23:

[[Category: Taylor, M E.]]

[[Category: Weis, W I.]]

[[Category: C-type lectin]]

[[Category: Carbohydrate-binding]]

[[Category: Sugar binding protein]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3p5f.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3p5f", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3p5f|  PDB=3p5f  |  SCENE=  }}
 ===Structure of the carbohydrate-recognition domain of human Langerin with man2 (Man alpha1-2 Man)===
+{{ABSTRACT_PUBMED_21112338}}
+==Disease==
+[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref><ref>PMID:16567809</ref>
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_21112338}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref><ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 21112338 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21112338}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:21112338</ref><references group="xtra"/>
+<ref group="xtra">PMID:021112338</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Drickamer, K.]]
@@ Line 32: / Line 23: @@
 [[Category: Taylor, M E.]]
 [[Category: Weis, W I.]]
+[[Category: C-type lectin]]
+[[Category: Carbohydrate-binding]]
+[[Category: Sugar binding protein]]