3qij: Difference between revisions

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~~[[Image:3qij.jpg|left|200px]]~~

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===Primitive-monoclinic crystal structure of the FERM domain of protein 4.1R===

===~~Primitive~~-~~monoclinic crystal structure~~ of ~~the FERM domain~~ of ~~protein 4~~.~~1R===~~

==Disease==

[[http://www.uniprot.org/uniprot/41_HUMAN 41_HUMAN]] Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:[http://omim.org/entry/611804 611804]]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:[http://omim.org/entry/266140 266140]]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.

==Function==

[[http://www.uniprot.org/uniprot/41_HUMAN 41_HUMAN]] Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.

==About this Structure==

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[[Category: Weigelt, J.]]

[[Category: Zhong, N.]]

[[Category: Cytoskeleton]]

[[Category: Sgc]]

[[Category: Structural genomic]]

[[Category: Structural genomics consortium]]

[[Category: Structural protein]]

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-[[Image:3qij.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3qij", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3qij|  PDB=3qij  |  SCENE=  }}
+===Primitive-monoclinic crystal structure of the FERM domain of protein 4.1R===
-===Primitive-monoclinic crystal structure of the FERM domain of protein 4.1R===
+==Disease==
+[[http://www.uniprot.org/uniprot/41_HUMAN 41_HUMAN]] Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:[http://omim.org/entry/611804 611804]]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.  Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:[http://omim.org/entry/266140 266140]]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
+==Function==
+[[http://www.uniprot.org/uniprot/41_HUMAN 41_HUMAN]] Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
 ==About this Structure==
@@ Line 25: / Line 21: @@
 [[Category: Weigelt, J.]]
 [[Category: Zhong, N.]]
+[[Category: Cytoskeleton]]
+[[Category: Sgc]]
+[[Category: Structural genomic]]
+[[Category: Structural genomics consortium]]
+[[Category: Structural protein]]