3qik: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3qik| PDB=3qik | SCENE= }} | {{STRUCTURE_3qik| PDB=3qik | SCENE= }} | ||
===Crystal structure of the first PDZ domain of PREX1=== | ===Crystal structure of the first PDZ domain of PREX1=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN]] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. | |||
==About this Structure== | ==About this Structure== | ||
| Line 25: | Line 18: | ||
[[Category: Tong, Y.]] | [[Category: Tong, Y.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: Hydrolase regulator]] | |||
[[Category: Pdz domain]] | |||
[[Category: Sgc]] | |||
[[Category: Structural genomics consortium]] | |||
Revision as of 08:32, 8 May 2013
Crystal structure of the first PDZ domain of PREX1
Function
[PREX1_HUMAN] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
About this Structure
3qik is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
