2gmv: Difference between revisions

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==Overview==
==Overview==
New modifications on the C-8 4-aminobenzyl unit of the previously reported, 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most, active compound reported here is the, 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with, an IC(50) of 0.29+/-0.08 microM. An X-ray analysis of a heteroaromatic, sulfonamide is presented showing a new pi-pi interaction.
New modifications on the C-8 4-aminobenzyl unit of the previously reported 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most active compound reported here is the 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with an IC(50) of 0.29+/-0.08 microM. An X-ray analysis of a heteroaromatic sulfonamide is presented showing a new pi-pi interaction.
 
==Disease==
Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=261680 261680]]


==About this Structure==
==About this Structure==
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[[Category: xanthine]]
[[Category: xanthine]]


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