Colicin M: Difference between revisions
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{{STRUCTURE_2xmx | PDB=2xmx | SCENE= Colicin_M/Colm/1 }} | {{STRUCTURE_2xmx | PDB=2xmx | SCENE= Colicin_M/Colm/1 }} | ||
Colicin M is a type of [[Colicin]], a bacteriocin made by ''E. coli'' which acts against other nearby ''E. coli'' to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. | Colicin M is a type of [[Colicin]], a bacteriocin made by ''E. coli'' which acts against other nearby ''E. coli'' to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. <scene name='Colicin_M/Colmsingle/1'>Monomer</scene> of Colicin M. | ||
Revision as of 14:44, 25 February 2011
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| 2xmx, resolution 1.67Å (default scene) | |||||||||||||
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| Ligands: | CO3, GOL | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Colicin M is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them by inhibiting synthesis of peptidoglycan - murein, preventing synthesis of the cell wall and ultimately leading to cell lysis. Monomer of Colicin M.
Synthesis and release
Mechanism of uptake
Killing Activities
ColM shows enzymatic properties of degradation of lipid I and lipid II peptidoglycan intermediates. The cleavage occurs between the lipid moiety and the pyrophosphoryl groups. This then leads to the arrest of peptidoglycan polymerisation[1], rather than the direct degradation of the peptidoglycan[2].
References
- ↑ El Ghachi M, Bouhss A, Barreteau H, Touze T, Auger G, Blanot D, Mengin-Lecreulx D. Colicin M exerts its bacteriolytic effect via enzymatic degradation of undecaprenyl phosphate-linked peptidoglycan precursors. J Biol Chem. 2006 Aug 11;281(32):22761-72. Epub 2006 Jun 15. PMID:16777846 doi:10.1074/jbc.M602834200
- ↑ Schaller K, Dreher R, Braun V. Structural and functional properties of colicin M. J Bacteriol. 1981 Apr;146(1):54-63. PMID:7012126
