3k8q: Difference between revisions

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~~[[Image:3k8q.png|left|200px]]~~

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===Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H===

===~~Crystal structure~~ of ~~human~~ purine nucleoside phosphorylase in ~~complex with SerMe-Immucillin H===~~

==Disease==

[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref><ref>PMID:1384322</ref><ref>PMID:8931706</ref>

==Function==

[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>

==About this Structure==

[[3k8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8Q OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Purine-nucleoside phosphorylase]]

Line 19:

[[Category: Ho, M.]]

[[Category: Scharmm, V L.]]

[[Category: Cytoskeleton]]

[[Category: Disease mutation]]

[[Category: Glycosyltransferase]]

[[Category: Hpnp]]

[[Category: Immucillin h]]

[[Category: Pnp]]

[[Category: Serme-immh]]

[[Category: Transferase]]

[[Category: Transition state analog inhibitor]]

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-[[Image:3k8q.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3k8q", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3k8q|  PDB=3k8q  |  SCENE=  }}
+===Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H===
+{{ABSTRACT_PUBMED_020212140}}
-===Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H===
+==Disease==
+[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[http://omim.org/entry/613179 613179]]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref><ref>PMID:1384322</ref><ref>PMID:8931706</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
 ==About this Structure==
 [[3k8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K8Q OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Purine-nucleoside phosphorylase]]
@@ Line 19: / Line 19: @@
 [[Category: Ho, M.]]
 [[Category: Scharmm, V L.]]
+[[Category: Cytoskeleton]]
+[[Category: Disease mutation]]
+[[Category: Glycosyltransferase]]
+[[Category: Hpnp]]
+[[Category: Immucillin h]]
+[[Category: Pnp]]
+[[Category: Serme-immh]]
+[[Category: Transferase]]
+[[Category: Transition state analog inhibitor]]