3mzs: Difference between revisions

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[[Image:3mzs.png|left|200px]]
<!--
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{{STRUCTURE_3mzs|  PDB=3mzs  |  SCENE=  }}  
{{STRUCTURE_3mzs|  PDB=3mzs  |  SCENE=  }}  
===Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol===
===Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol===
{{ABSTRACT_PUBMED_21159775}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/CP11A_BOVIN CP11A_BOVIN]] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.  
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{{ABSTRACT_PUBMED_21159775}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:21159775</ref><references group="xtra"/>
<ref group="xtra">PMID:021159775</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Annalora, A.]]
[[Category: Annalora, A.]]
Line 28: Line 16:
[[Category: Pikuleva, I.]]
[[Category: Pikuleva, I.]]
[[Category: Stout, C D.]]
[[Category: Stout, C D.]]
[[Category: Cholesterol]]
[[Category: Cholesterol 20-22-desmolase]]
[[Category: Cyp11a1]]
[[Category: Cytochrome p450]]
[[Category: Heme]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
[[Category: Side chain cleavage enzyme]]
[[Category: Steroid metabolism]]

Revision as of 20:58, 17 April 2013

Template:STRUCTURE 3mzs

Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol

Template:ABSTRACT PUBMED 21159775

Function

[CP11A_BOVIN] Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

About this Structure

3mzs is a 4 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  1. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem. 2010 Dec 15. PMID:21159775 doi:10.1074/jbc.M110.188433

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