3laf: Difference between revisions
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{{STRUCTURE_3laf| PDB=3laf | SCENE= }} | {{STRUCTURE_3laf| PDB=3laf | SCENE= }} | ||
===Structure of DCC, a netrin-1 receptor=== | ===Structure of DCC, a netrin-1 receptor=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q63155_RAT Q63155_RAT]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).<ref>PMID:8861902</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3laf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAF OCA]. | [[3laf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAF OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Chen, Q.]] | [[Category: Chen, Q.]] | ||
[[Category: Liu, J H.]] | [[Category: Liu, J H.]] | ||
[[Category: Wang, J H.]] | [[Category: Wang, J H.]] | ||
[[Category: Apoptosis]] | |||
[[Category: Horseshoe]] | |||
[[Category: Immunoglobulin superfamily]] | |||
[[Category: Netrin-1 receptor]] | |||
Revision as of 20:19, 4 April 2013
Structure of DCC, a netrin-1 receptor
Function
[Q63155_RAT] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).[1]
About this Structure
3laf is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
